8-(2-Methylbutanoyl)-3, 10 Epoxy-3, 8-Dihydroxyl-4, 11 (13)- Germacradien-12, 6-Olide A New Sesquiterpene Lactone From Tithonia diversifolia

Abstract

Tithonia diversifolia (Hemsl.) A. Gray is known to contain sesquiterpene lactones and related compounds. A new sesquiterpine lactone 8-(2-methylbutanoyl)-3, 10 Epoxy-3, 8-dihydroxyl-4, 11 (13)- germacradien-12, 6-olide was isolated from the aerial part of the plant. The structure was established by spectroscopic methods.

Key words: Tithonia diversifolia, Asteraceae, sesquiterpine lactone, 8-(2-methylbutanoyl)-3, 10 Epoxy-3, 8-dihydroxyl-4, 11 (13)- germacradien-12, 6-olide, Malaria

Nig. J. Nat. Prod. and Med. Vol.8 2004: 74-76