JK Adesanwo
Discipline of Chemistry, School of Physical Sciences, University of KwaZulu-Natal, Westville Campus, P/Bag X54001, Durban 4000, South Africa
O Ekundayo
Department of Chemistry, University of Ibadan, Nigeria
FO Shode
Discipline of Chemistry, School of Physical Sciences, University of KwaZulu-Natal, Westville Campus, P/Bag X54001, Durban 4000, South Africa
VCO Njar
Departmenof Pharmacology & Expt. Therapeutics, University of Maryland, Baltimore School of Medicine, 655 West Baltimore Street Baltimore, MD 21202-1559 U.S.A
AJJ van den Berge
Department of Medicinal Chemistry, Faculty of Pharmacy, Universiteit Utrecht, P.O. Box 80082, 3508 TB Utrecht, The Netherlands
AT Oludahunsi
Postgraduate Institute for Medical Research and Training (PIMRAT), College of Medicine, University of Ibadan, Nigeria
Abstract
The chloroform soluble portion of methanolic extract of the root bark of Quassia undulata Simaroubaceae, gave four compounds: scopoletin 1, glaucarubinone 2, 15-desacetylundulatone 3 and a new coumarin, eniotorin 4. The structures were determined by analysis of the spectroscopic data. The aqueous extract and the isolated compounds exhibited dose-related effect against the P. falciparum malaria parasite in an in-vitro antimalarial assay.
Key words: Eniotorin, Quassia undulata, Simaroubaceae, anti-malaria, simaroubaceae.
Nig. J. Nat. Prod. and Med. Vol.8 2004: 69-73