Olusola Ladeji
Department of Biochemistry, University of Jos, P.M.B. 2002, Jos. Plateau state, Nigeria
SC Zebulon
Department of Biochemistry, University of Jos, P.M.B. 2002, Jos. Plateau state, Nigeria
Francis Uddoh Okoye
Department of Pharmacology, University of Jos.
Abstract
Oral and intravenous administration of the stem bark extract of Vitex doniana produced a dose-dependent hypotensive effect in both normotensive and hypertensive rats. The blood pressure was markedly reduced and the level maintained for longer duration when the extract was administered intravenously to hypertensive rats.
Key Words: Vitex doniana, smooth muscle, blood pressure, antihypertensive
Nig. J. Nat. Prod. And Med. Vol.1 1997: 19-20