EFFECT OF BRIDELIA FERRUGUBEA STEM BARK ON BLOOD CHEMISTRY AND HISTOLOGY OF SOME ORGANS IN RATS

Abstract

Aqueous extract of Bridelia ferruginea stem bark caused significant increases in serum K⁺, creatinine, total bilirubin, GOT, GPT, HDL, Alkaline phosphate, BUN (p<0.001) and decreases in serum Na⁺, Cl^-, CO₂2+ (p<0.01,0.001) in rats. No changes were observed in serum triglyceride, uric acid, phosphate and total protein levels when compared with the control. The increase in some if these parameter was detected by means of PAS staining. The heart and lungs also showed adverse effects.


Key Words: Bridelia ferruginea, Euphorbiaceae, blood chemistry, rat lungs and heart


Nig. J. Nat. Prod. And Med. Vol.2 1998: 26-28