NOVEL AND BIOACTIVE METABOLITES OF WARBURGIA SALUTARIS INDIGENOUS TO THE NORTHERN PROVINCE, SOUTH AFRICA

Abstract

The stem bark of Warburgia salutyaris (Bertol. F. Chiov.) collected in Zoutpansberg mountains, South Africa, yielded a new drimane sessquiterpenoidd lactone, salutarisolide, along with four known drimane sesquiterpenoids warburganal, mukaadial, polygodial and isopolygodial. The structure of salutarisolide was fully characterized from its spectral data. The lactone is structurally related to muzigadial.


Keywords — Warburgia salutaris; Canellaceae; salutarisolide; warburganal; muzigadial; polygodial; isopolygodial; NMR; INAPT; NOE; COSY.


Nig. J. Nat Prod. And Med. Vol.3 1999: 28-30