EFFECT OF SCOPOLETIN ON ERTHROCYTE MEMBRANE ION MOTIVE ATPASES

Abstract

The effect of scopoletin, a naturally occurring coumarin in cassava (Manihot esculenta) and its products, on erythroacyte membrane ion motive ATPases was investigated. Sopoletin significantly, stimulated the activities of the ion motive ATPASES (P<0.05). It stimulated Ca-and Mg-ATPase at 0.1 mM and Na-K-ATPase at 0.25mM concentration. The stimulatory effect was more on Na-K-ATPase, followed by Ca-ATPase. Since ion motive ATPases contribute to erythrocyte structure and functions, the presence of scopoletin in cassava and other products could have health implications.


Key Words: Coumarin, scopoletin, ion motive ATPases: Na-K-ATPase, Ca-ATPase


Nig. J. Nat Prod. And Med. Vol.5 2001: 37-40