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The Clinical and Laboratory Features of Plasma Cell NeoplasiaIn the University of Port Harcourt Teaching Hospital
Abstract
OBJECTIVE: To analyze the clinical and laboratory features of Multiple Myeloma at presentation in a tertiary centre in Port Harcourt, Southern Nigeria.
METHODS: The medical records of all patients diagnosed for plasma cell neoplasia within a 10 year period at the University of Port Harcourt Teaching Hospital were reviewed retrospectively. Clinical presentation, investigation results, support and specific therapy used were documented.
RESULTS: A total of 20 patients were diagnosed with multiple myeloma, 70% were males, the mean age was 61.30 + 8.8 years, 50% of them had pathological fractures. The mean duration before presentation was
11.89 + 11.7 months (Median = 7 months) and associated with poor outcome. The most common method of treatment was chemotherapy with Melphalan and Prednisolone.
CONCLUSION: MM is a disease of the elderly that can negatively impact on the quality of life due to the complications associated with it. A long duration of symptoms before presentation is a common problem and
it has been associated with substantial morbidity and mortality in this study.
METHODS: The medical records of all patients diagnosed for plasma cell neoplasia within a 10 year period at the University of Port Harcourt Teaching Hospital were reviewed retrospectively. Clinical presentation, investigation results, support and specific therapy used were documented.
RESULTS: A total of 20 patients were diagnosed with multiple myeloma, 70% were males, the mean age was 61.30 + 8.8 years, 50% of them had pathological fractures. The mean duration before presentation was
11.89 + 11.7 months (Median = 7 months) and associated with poor outcome. The most common method of treatment was chemotherapy with Melphalan and Prednisolone.
CONCLUSION: MM is a disease of the elderly that can negatively impact on the quality of life due to the complications associated with it. A long duration of symptoms before presentation is a common problem and
it has been associated with substantial morbidity and mortality in this study.
