Chemical compositions from the leaf extracts ofFuntumiaafricana(Benth.) stapf with its antioxidant and anti-inflammatory activity.

Abstract

Antioxidant and anti-inflammatory activity of the extracts of Funtunmiaafricana(Benth.) stapfleaves were investigated in this study. The leaf part of Funtunmiaafricanawere dried, weighed, and exhaustively extracted with n-hexane and chloroform. GC-MS analysis of the extracts was carried out to know the number of compounds present in the extract as well as their molecular formula. These extracts of the plant were evaluated for antioxidant and anti-inflammatory activity using peroxide scavenging, lipoxidase and membrane stabilization. Hexane extract showed antioxidant activity with IC₅₀ of 194.09 μg/mL. Hexane and chloroform extracts also showed pronounced anti-inflammatory activity. The GC-MS analysis of the plant extracts showed the presence of twenty-eight compounds in chloroform extract, with terpenoids, fatty acids and unsaturated hydrocarbons as its principal components, while seven compounds were revealed in hexane extract of the plant, and its most abundant compound is 1,2-Benzenedicarboxylic acid, bis(2- methylpropyl)ester.

Keywords: Antioxidant activity, anti-inflammatory activity, α-bisabolol, 13-methyl pentadecanoic acid, GC-MS.