Comparative evaluation of the susceptibility pattern of commonly used antibiotics in the treatment of urinary tract infection.

Abstract

The agar disc diffusion method was used to evaluate the susceptibility pattern of commonly used standard antibiotics with the aim of identifying the most effective to address the problem of resistance. A total of two hundred and twenty (220) urine samples collected from 44 Army Reference Hospital and Yusuf Dantsoho Memorial Hospital, Kaduna Nigeria were evaluated and one hundred and forty one (141) samples were found to be positive for the presence of Escherichia coli and Staphylococcus aureus. Results of the sensitivity of the antibiotics showed highest zone of inhibition of 26±0.05mm due to the bioactivity of Pefloxacin (10μg) and the least zone of inhibition of 23±0.00mm due to the bioactivity of Zinnacef (20μg) against S. aureus while E.coli isolated from the positive samples had highest zone of inhibition of 26 ± 0.50mm due to the activity of Chloramphenicol at 30μg concentration level and the least activity was observed due to the effect of Augmentin at 30μg concentration level. Resistance was observed in the case of Amoxicillin, Pefloxacin and Tarivid against E.coli. In the case of S.aureus, resistance was observed when Ampiclox was used. The choice of antibiotic to treat urinary tract infection should be considered based on the susceptibility of the organism to the antibiotic.