Vitamin B12 deficiency presenting with Myeloneuropathy

Abstract

The neurologic manifestations of vitamin B12 deficiency, although uncommon, are the result of its effects on the brain, optic nerves, peripheral nerves, and spinal cord. Myeloneuropathy, resulting in sensory disturbances, weakness, and spasticity, is known as subacute combined degeneration and primarily involves the dorsal, and lateral spinal columns as well as the peripheral nerves. Subacute combined degeneration is treatable and the symptoms are potentially reversible if detected at an early stage. We present the clinical as well as the laboratory findings in a patient with subacute combined degeneration who had resolution of the clinical neurological manifestations with B12 therapy.