Effect of resveratrol on haematological changes in diabetic-malaria infected wistar rats

Abstract

The effect of resveratrol on haematological changes in diabetic-malaria infected rats was investigated. Five of six groups of male Wistar rats were induced with type 2 diabetes, followed by inoculation with malaria parasites. Four groups of the diabetic-malaria infected rats were orally given: low dose resveratrol (50 mg/kg), high dose resveratrol (100 mg/kg), Metformin (100 mg/kg) and Artesunate (5 mg/kg) respectively for six days after malaria inoculation. Administration of resveratrol, metformin and artesunate to diabetic-malaria infected rats significantly (p < 0.05) decreased the blood glucose level (BGL) on days 3 and 6 post-inoculation. The high dose resveratrol (RSV 100) group showed a significant (p<0.05) increase in red blood cell counts, although a significant (p < 0.05) decrease of Packed Cell Volume was recorded in the low dose resveratrol group.  There was no significant (p>0.05) difference for the values of total WBC counts across the four groups of the diabetic-malaria infected rats, but the differential WBC counts (dWBCC) were significantly (p<0.05) affected. High dose resveratrol administration significantly (p < 0.05) reversed the dWBCC. The diabetic-malarial infected group showed significant (p<0.05) decrease in average RBC; the average parasites and average infected RBC counts were significantly (p<0.05) higher than that in the resveratrol groups. While, Metformin and Artesunate groups showed a further decline in parasitaemia. These findings indicate that Resveratrol decreased BGL and improved hematological parameters and suppressed parasitaemia in diabetic-malarial infected rats.