Evaluation of Prothrombin Time and Activated Partial Thromboplastin in Patients with Diabetes Mellitus

Abstract

Diabetes mellitus is a heterogeneous disorder that affects cellular metabolism in variety of ways, and coagulation indices are reported to be adversely affected. In the current study prothrombin time (PT) and activated partial thromboplastin time (APTT) were investigated in treated and untreated diabetics as well as in non diabetic controls. Using clot based assay technique, PT was 20.620± 2.849, 16.720±2.339, and 14. 920±1.209 in untreated, treated and in non diabetic controls respectively. There were statistically significant differences (p<0.05) between the untreated and treated diabetics as well as between untreated and non diabetic controls. APTT was 58.460±4.146, 43.260±5.587 and 41.380±4.295 in untreated, treated and in non diabetic controls respectively. There is statistically significant difference (p>0.05) between untreated and treated diabetics (p<0.05).Value of treated and controls are not significantly difference (p>0.05). Our finding suggest an abnormal PT and APTT in untreated patients with diabetes mellitus.