Effect of Supplementation with a Locally Prepared Nutriceutical on Renal Function Profile in Alloxan-Induced Diabetic Rats

Abstract

Diabetes mellitus is characterized by increased levels of marker of oxidative stress which play a role in the development of diabetes complications. Antioxidants are thought to be beneficial in curtailing the lipid peroxidation. In the current work, antioxidant- rich nutriceutic was formulated from onions, garlic, lemon, palm oil and crayfish (in ratio 6:6:2:1:5 respectively), which are known sources of vitamins A, C and E and Cu, Cr, Mn and Zn. The nutriceutic was administered to alloxan-induced diabetic rats for 3 weeks and the effect of the supplementation on renal function profile was studied. The results shows that supplementation significantly (P<0.05) reduced blood glucose, urea, creatinine and potassium. It also not significantly (P>0.05) reduced serum sodium and bicarbonate. The findings suggest that supplementation with naturally occurring antioxidant nutriceutic may reduce the risk of oxidative stress and complications associated with diabetes mellitus and might be beneficial in the routine treatment of diabetes mellitus patients.

Keywords: Diabetes, nutriceutic, glucose, and renal function profile

Nigerian Journal of Basic and Applied Science (2011), 19 (2): 197- 201