Toxicity Studies of the Crude Aqueous Root Extract of Albizzia chevalieri Harms in Albino Rats

Abstract

Aqueous root extract of Albizzia chevalieri has been reported to possess hypoglycaemic and hypolipidaemic effects. The current work investigated the LD50 of the crude aqueous root extract of Albizzia chevalieri and the effect of sub-chronic doses of the extract on liver and kidney function parameters of albino rats. The results indicated LD50 greater than 3000mg/kg body weight in albino rats observed for 72 hours. The result of the sub-chronic toxicity on liver function parameters showed significant (P<0.05) increase in serum total protein and globulin at doses greater than 2000mg//kg, which was reflected on the A:G ratio. Transaminases and alkaline phosphatase activities were also significantly (P<0.05) affected at doses greater than 2000mg/kg. Serum levels of urea were also increased significantly (P<0.05) but creatinine and uric acids were
decreased significantly (P<0.05) at doses greater than 2000 mg/kg., Serum electrolytes were however not affected. The extract should therefore be use with care especially at doses greater than 2000 mg/kg.