Effect of Syzygium guineense and Borassus aethiopum leaves on protein glycation and oxidative stress suppression

Abstract

The quest for discovery of a new antiglycation and antioxidant drug still remains a major priority in medicine and related clinical sectors. Against this backdrop, the antioxidant and antiglycation activities of ethylacetate, chloroform, methanol and aqueous extracts of Syzygium guineense (SG) and Borassus aethiopum (BA) leaves including their phytochemical compositions were evaluated in an in vitro trial. DPPH free radical scavenging capacity, antiglycation activity and qualitative phytochemical screening in vitro assay were employed respectively. Our result revealed that triterpenes, cardiac glycosides, tannins and flavonoids were detected in the plants leaves extracts. The extracts demonstrated a significantly (p < 0.05) low antioxidant and antiglycation activities except the aqueous extract of BA leaves, which displayed a significantly (p < 0.05) high antiglycation ability. Overall, data from the current study showed that ethylacetate, chloroform, methanol and aqueous extracts of the plants leaves have potential effect towards lowering oxidative stress and protein glycation and thus should be exploited for further research in the area of drug discovery.