Ameliorative Effect of Aqueous Seed Extract of Citrullus Lanatus (Water Melon) on Liver Function Parameters and Markers of Oxidative Stress in Lead Treated Rats

Abstract

Extensive and unmonitored use of lead in developing and industrialized countries is posing a serious threat to human health. Prolonged exposure of a sub-lethal dose of this toxicant is closely related to its accumulation in various soft tissues and its interference with bio elements that hamper several physiological processes. The study was designed to investigate the potential effect of aqueous seed extract of Citrullus lanatus on liver function parameters and oxidative stress markers. Forty healthy albino rats of both sexes were randomly divided into four groups: Group 1: Normal, Group 2 Lead untreated, dose 15mg/kg lead acetate. Group 3 and 4 were dosed 15mg/kg lead acetate and aqueous seed extract 50mg/kg and 100 mg/kg respectively for 21 days. The present study revealed that AST, ALT and ALP levels were significantly increased (P < 0.05) in lead induced untreated group compared to control. There was no observed difference in serum total proteins (P > 0.05) among all the groups but albumin, significantly decreased (P < 0.05) compared to control. Serum vitamin A and E concentration were shown to have decreased in lead untreated groups while Vitamin C level remained unchanged. The level of GSH and catalase activity increased in the treatment groups with decreased in MDA level. It is therefore suggested that aqueous seed extract of water melon might be rich in antioxidants, hence effective in preventing lipid peroxidation.

Keywords: Antioxidants, Citrullus lanatus, Lead, Oxidative stress.