Article Sidebar
Published:
Mar 30, 2024Keywords:
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
NAJ supports free online communication and exchange of knowledge as the most effective way of ensuring that the fruits of research and development practice are made widely available. It is therefore committed to open access, which, for authors, enables the widest possible dissemination of their findings and, for readers, increases their ability to discover pertinent information. The Journal adopts and uses the CC: BY license and is open access. This license lets others distribute, remix, adapt, and build upon your work, even commercially, as long as they credit you for the original creation. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the Journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work. Copyright for articles published in this Journal is retained by the Journal.
Main Article Content
Impact of Newbouldia laevis Root Extract on Hematological Parameters in Rats: A Comprehensive Study on Dosage-Dependent Effects and Long-Term Dynamics
Abstract
Haematological parameters serve as crucial indicators for evaluating essential data related to the body's response to illnesses and medications. This study aimed to investigate the impact of Newbouldia laevis root extract on the haematological parameters of rats. A total of sixteen male Wistar rats were randomly divided into four groups, each comprising four rats. The control group, designated as the first group, received only feed and water, while groups two, three, and four were administered doses of 200, 400, and 600 mg/kg of N. laevis root extracts, respectively. Upon assessing the percentage packed cell volume fourteen days post-extract administration, no significant variations (p > 0.05) were observed among the groups. However, after administering the extract for 14 days, the control group and the 600 mg/kg-treated group exhibited significantly lower red blood cell counts and haemoglobin values (p < 0.05) compared to the groups treated with 200 mg of the extract. Notably, at 28 days post-administration, there were no significant differences (p > 0.05) in the percentage packed cell volume, red blood cell counts, or haemoglobin values among the groups, despite the observed disparities on the 14-day. Furthermore, a significant increase in percentage packed cell volume, red blood cell counts, and haemoglobin values was noted when the values were compared at 14 and 28 days. The study contributes significantly to our understanding of the plant extract's effects on the physiological components of the haematological system.
