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Main Article Content
Effect of Aqueous Leaf Extract of Adansonia digitata (Baobab) on Some Biochemical and Haematological Indices of Alloxan-Induced Diabetic Rats
Abstract
The study aimed to investigate the effect of aqueous leaf extract of Adansonia digitata on some haematological
and biochemical indices of alloxan-induced diabetic rats. Twenty-five (25) male albino rats (mean weight;
130±0.1 g) were divided into five (5) groups (n=5). Diabetes was induced in rats with 150 mg/Kg of alloxan
(Group 2, 3, 4 and 5). Group 1 was the normal control and received only feed and water. Group 2 was untreated
and received feed and water after induction. Group 3 was treated with glibenclamide; Group 4 was treated with
200mg/kg of plant extract, while Group 5 was treated with 400mg/kg of plant extract. Treatment was done for
twenty-one (21) days, after which animals were bled and blood samples collected and used for parameters
analysis. Results revealed a significant (p>0.05) decrease in body weight, Blood Glucose level, WBC, MDA and
Total Protein level of group 2 compared with the normal control, while no significant difference was observed in
the parameters in group 4 and group 5 as against group 1. The result suggests that the aqueous leaf extract of A.
digitata was capable of normalizing some haematological and biochemical abnormalities associated with
diabetes in rats. It was further suggested that leaf extract of A. digitata could be prescribed as an adjunct to dietary
therapy and main therapy for diabetes.
