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Apr 30, 2022Keywords:
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Main Article Content
Haematological Values, Biochemical Parameters And Antioxidant Enzymes Concentration In Alloxan-Induced Diabetic Rats Treated With Chrysophyllum albidum Leaf Extracts
Abstract
In this study, the anti-diabetic effects of three solvents (petroleum ether, ethanol and chloroform) extracts of Chrysophyllum albidum leaves were evaluated on alloxan induced diabetic rats. Thirty wistar rats of both sexes were assigned to 6 groups (A-F) of 5 rats each. Group A (normal rats) and groups B-F made diabetic via single dose administration of alloxan monohydrate (160 mg/kg). Group B (diabetic control) Groups C, D and E were treated with 500 mg/kg body weight of petroleum ether, ethanol and chloroform extract of Chrysopyllum albidum respectively. Group F was administered glibenclamide (3 mg/kg). All treatments were oral and lasted 14 days. Elevated blood glucose concentrations in the diabetic rats were significantly lowered following treatment with no significant difference observed in the activities of the different extracts (P>0.05). Treatment with the extracts caused further fall in the values of the already decreased red blood cell parameters (RBC, PCV and Hb) with the chloroform extract causing the highest fall and petroleum ether extract the least. WBC count was only significantly (P<0.05) higher in groups treated with petroleum ether and chloroform extracts. Elevations in AST, ALP, bilirubin, urea, creatinine, sodium, chloride, potassium, cholesterol and triglycerides concentrations observed in the diabetic rats were also significantly(P<0.05) lowered following treatment with the extracts (P<0.05). All extracts also significantly improved the antioxidant strength of the diabetic treated rats. Chrysophyllum albidum may therefore be of value in the management of diabetes mellitus and its associated haematological and biochemical anormalies but should be used along with a haematinic agent.
