Histopathological alterations in intestine of mice infected with of Schistosoma mansoni

Abstract

Schistosomiasis remains an important health problem in many tropical countries and developing countries. It has serious pathological lesions in different tissues particularly liver. The aim of this study is to demonstrate histopathological alterations in intestine of mice infected with S. mansoni as model for human schistosomiasis. Twenty mice were infected by tail immersion technique (80±10 cercariae per mouse of Egyptian strain of S. mansoni). Animals were clinically observed for 7 weeks and then they were sacrificed. Gross and histological examination was done, in addition to Masson trichrome and scoring of fibrosis by image J analysis were performed. The results revealed severe weight loss of infected mice compared to control one, large number of neutrophiles in granuloma of S mansoni in intestinal submucosa, extensive fibrosis, about 12% from total area of intestine, that penetrate deeply into muscle layer. it was concluded that S. mansoni caused pyogranulomatous enteritis and extensive fibrosis that extended deeply into muscle layer of intestine.