Genotoxicity of bispyribac sodium in albino rats

Abstract

Genotoxicity of pesticides constitute great concern that affect population health, commercial formulation of such pesticides may increase the genotoxicity of certain pesticides, the genotoxic effect of bispyribac sodium had been studied in albino rats given orally 65.88, 32.94 and 16.47 mg/kg of bispyribac sodium twice per week for 3 months and the results indicated that significant increase in chromosomal aberration (break, fragment, gap, ring and chromosomal association) in respect to control which was dose dependent also significant increase in DNA quantity, also there was significant increase in micronuclei level in respect to control and decrease in mitotic activity in bone marrow cell where the mitotic index had decreased drastically in response to control value and these results confirm that bispyribac sodium may have genotoxic effect affect in albino rats.