Chloroquine Induced Lipid Deposition in the Lateral Geniculate Body and Superior Colliculus of Adult Wistar Rats

Abstract

Abstract: The effect of administration of chloroquine on lipid deposition was studied in intracranial visual relay centers. Adult Wistar rats (38) weighing averagely 200g were randomly assigned into treatment (28) and control (10) groups. The rats in the treatment groups received 2mg/kg body weight of chloroquine phosphate in distilled water for 13 days. The rats were sacrificed on days 1,3,5,7,9,11 and 13. The lateral geniculate body and the superior colliculus were dissected out and frozen. Frozen sections were stained with Sudan Black B. Results obtained showed that prolonged administration of
chloroquine caused increased and diffused lipid deposition in these tissues especially on the 13th day treatment group. This lipid deposition may interfere with the normal functions of these visual relay centers.