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Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy


Wongani J.S. Nyangulu
Edson Mwinjiwa
Titus H. Divala
Randy G. Mungwira
Osward Nyirenda
Maxwell Kanjala
Gillian Mbambo
Jane Mallewa
Terrie E. Taylor
Matthew B. Laurens
Miriam K. Laufer
Joep J. van Oosterhout

Abstract

We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether–lumefantrine may have played a causative role in the recurrent malaria our patients experienced.


Journal Identifiers


eISSN: 1995-7262
print ISSN: 1995-7270