Effect of resveratrol on total protein and albumin in type 2 diabetes wound healing in rats

Abstract

Resveratrol, a polyphenol predominantly present in red grapes, has attracted interest due to its possible health advantages. The anti- inflammatory, antioxidant, and vasodilatory properties of this substance indicate that it may have a beneficial effect on wound healing in  individuals with diabetes mellitus. This study aims to determine the role of resveratrol on type 2 diabetic wound healing on total protein  and albumin levels in rats. 20 male adult Albino Wistar rats were rendered diabetic using a high-fat diet and an alloxan injection (120 mg/ kg). The rats were grouped into four: non-diabetic control group (negative control), diabetic control group (positive control), diabetic treatment group 1 (resveratrol: 10 mg/kg) and diabetic treatment group 2 (resveratrol: 20 mg/kg). Excisional wounds were created and  monitored for wound closure over a defined treatment period of 14 days. Studies were conducted and expressed using physical and  biochemical indices. The data demonstrated wound healing activities via biochemical indices, and histological and macroscopic methods.  There was a difference in fasting blood glucose between the diabetic control group with the treatment groups. There was a difference  between the diabetic control group compared to the group treated with resveratrol 10 mg/kg and 20 mg/kg in the weight of the rats.  There was no significant acceleration in total albumin and globulin levels in the diabetic wounded group treated with resveratrol (10 mg  and 20 mg). The resultssuggest that resveratrol treatment does not affect on total albumin and globulin levels in diabetic rats.