A collective review of the synthetic approaches disclosed in prior patents to synthesize the renowned drug, Lamotrigine

Abstract

In this review work, we have extracted the essential details from prior patents about the synthesis of popular drug Lamotrigine. This  initiative will provide a platform for the global researchers to invent new or innovate over the existing synthetic routes to isolate  Lamotrigine with good yield and purity. The details of patents were sourced from “Google patents” search tool and the process specific  details were elaborated with reaction schemes. In this context, twenty-four reactions schemes were tabulated for the better  understanding of the disclosed ventures. The entire chronological exfoliation of details on the synthesis of Lamotrigine provides a clear  evolutional vision of its synthetic flourish towards drug commercialization.