Anti-inflammatory Effect of Angelica Shikokiana Makino Leaves Extract Gel on Lichen Planus Induced Oral Mucositis (Clinical Study)

Abstract

Objective: To develop eco-friendly nanoemulsions of Angelica shikokiana natural extract gel and evaluate its antiinflammatory activity by assessing the reduction of the present oral mucositis induced by oral lichen planus (OLP).

Patients and methods: In all 34 patients with OLP participated in this randomized controlled trial, classified into two main groups. The  first group (study group) was given the prepared gel of A. shikokiana Makino (AS) leaves extract in orabase. The second group (control  group) was given 0.1 % triamcinolone acetonide (TA), known as kenacort in orabase. Clinical improvement was evaluated using the  Thongprasom scale, and pain reduction was recorded using a numeric rating scale. Initial, midway, and final assessments were  performed on the patients. Also, the serum level of interleukin six was evaluated at the baseline and the end of the study.

Results:  Statistical analysis showed that both groups' pain scores, overall lesion sizes, and Thongprasom scores improved with time. There was a  statistically significant difference between week 2 and week 4 reports of improvement in the TA group and AS group (P value was ≤ 0.05)  indicating that the trend towards better health persisted through week 4. TA's analgesic impact was superior to AS's during the second  week, but by the fourth week, AS had caught up to TA. At the end of the research period, both treatments significantly reduced lesion size  (P value ≤ 0.005) in both groups There was a practical improvement in the oral mucositis associated with OLP in all patients after  treatment with our gel. There was no significant difference between the serum level of interleukin six at the baseline and the end of the  study (P value 0.71825).

Conclusion: AS can be used as a treatment for OLP. It can be utilized as a backup plan in OLP when  corticosteroids are not working or when individuals decline therapy for fear of adverse effects.