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The Effect of Clerodendrum Myricoides Aqueous Extract on Blood, Liver and Kidney Tissues of Mice
Abstract
collected in Bale area, Ethiopia dried and crushed into powder and soaked in water to yield aqueous extract. The extract was then administered to mice at doses of 100 and 400mg/kg
bw/day for six weeks and 1134mg/kg bw/day (LD50) once. The 400mg/kg bw/day and LD50 treated mice showed hypoactivity (abnormally diminished activity), grooming, prostration
(submissively prone position), piloroerection (elevation of hairs) and irritation, while 100mg/kg bw/day treated mice showed no behavioral changes. The dose of 100mg/kg bw/day produced
significant weight gain, while 400mg/kg bw/day produced significant weight lost in chronic administration. The extract increased only urea at the dose of 100mg/kg bw/day, whereas it
increases most hematological and biochemical parameters at 400mg/kg bw/day. The extract, however did not show significant change in platelet, HGB and MCHC value at both doses. Several histopathological changes in liver and kidney were also observed at both doses of the extract. There were inflammation and hydropic degeneration of hepatocytes at both doses. The LD50 of the extract produced hemorrhages and congestion in the glomeruli of the kidney.
