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Feb 6, 2025Keywords:
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Main Article Content
The analysis of PON1 gene expression and rs662 polymorphism in Iranian patients suffering from cardiovascular diseases
Lena Mahya
Elham Moslemi
Kasra Esfahani
Sedigheh Ahmadpour
Abstract
In addition to lifestyle and diet, cardiovascular disease can be caused by genetic factors related to heart function issues and the blood biochemical content. The PON1 gene encodes paraoxonase1 as an HDL-depended enzyme inhibiting LDL oxidation and relative side effects. The polymorphism of PON1 can significantly influence the activity and the levels of serum PON1, as well as the occurrence of cardiovascular disease. Therefore, this study analyzed PON1 gene expression and Q192R polymorphism among Iranian cardiovascular patients. This case-control research included 40 patients and 40 controls. The Q192R polymorphism of the PON1 gene was analyzed by real-time PCR. In addition, PON1 gene polymorphism was analyzed by the developed methodology for PCR and RFLP. The data was statistically analyzed by t-test (P <0.05) via SPSS version 23.0. The expression of PON1 was considerably reduced in the patients (P < 0.05), compared to the control population. Additionally, there was a significant correlation between the expression of the gene, LDL level, and the age of the patients (P < 0.05). The low PON1 gene expression can indicate that the enzyme is a key factor positively affecting cardiovascular diseases among the Iranian population. Additionally, cardiovascular diseases in the Iranian population are significantly associated with the PON1 gene polymorphism.
