Neonatal thrombocytopenic purpura: report of two cases and review of literature

Abstract

Severe neonatal thrombocytopenia is a hematological emergency that can be due to increased platelet destruction(such as immune-mediated and peripheral platelet consumption) or
congenital failure of platelet production. The definitive diagnosis of the underlying cause of neonatal thrombocytopenic purpurais based on both clinical and laboratory findings.Case
report; We present two infants with persistent severe thrombocytopenia of distinct aetiologies: neonatal alloimmune thrombocytopenic purpura and hepatitis B virus exposure. Their clinical course, haematological profile and treatments are discussed.Conclusion: This reportreiterates the need to think laterally while considering the differential diagnoses of neonatal thrombocytopenic purpura. Moreover, ithighlightsits treatment challenges in peripheral health facilities, especially in resource-limited settings.