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Keywords:
Paullinia pinnata resistance modulators friedelin Staphyloccocus aureus.
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The copyright of a submitted article is only transferred to the publishers if and when the article is accepted for publication. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, mechanical, photocopying, recording or otherwise without the prior written permission of the publishers.
Main Article Content
Friedelin: A bacterial resistance modulator from Paulinia Pinnata L.
Abstract
As part of the project to identify plant natural products which modulate bacterial multidrug resistance (MDR), bioassay-guided isolation of the methanol extract of Paullinia pinnata L. roots yielded four known compounds namely friedelin, â-sitosterol, â-sitosterol acetate and â-sitosterol Dglucoside. The structures were established by spectroscopic methods and comparison with published data. These compounds were tested for in vitro antibacterial and resistance modifying activities against strains of Staphylococcus aureus; SA1199B, RN4220 and XU212 possessing the Tet(K), Msr
(A), and Nor(A) multidrug resistance efflux mechanisms respectively. At 10ìg/ml, none of the compounds displayed any antibacterial action but in combination with tetracycline, erythromycin and
norfloxacin, friedelin displayed a 2-fold, 4-fold and 16-fold potentiation of activities of these antibiotics against XU212, SA1199B and RN4220 possessing the Tet(K) [tetracycline resistant], Nor(A)
[norfloxacin resistant] and Msr(A) [macrolide resistant] transporters respectively.
(A), and Nor(A) multidrug resistance efflux mechanisms respectively. At 10ìg/ml, none of the compounds displayed any antibacterial action but in combination with tetracycline, erythromycin and
norfloxacin, friedelin displayed a 2-fold, 4-fold and 16-fold potentiation of activities of these antibiotics against XU212, SA1199B and RN4220 possessing the Tet(K) [tetracycline resistant], Nor(A)
[norfloxacin resistant] and Msr(A) [macrolide resistant] transporters respectively.
