Article Sidebar
Published:
May 26, 2008Keywords:
BeWo cells Trophoblast Morphology Matrigel Implantation
Article Details
Issue
Section
Articles
Copyright of the journal's content belongs to Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
The copyright of a submitted article is only transferred to the publishers if and when the article is accepted for publication. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, mechanical, photocopying, recording or otherwise without the prior written permission of the publishers.
The copyright of a submitted article is only transferred to the publishers if and when the article is accepted for publication. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, mechanical, photocopying, recording or otherwise without the prior written permission of the publishers.
Main Article Content
Morphological and Behavioural Features of Bewo Cells Grown on Matrigel Offers a Model for Human Cytotrophoblast Cells During Early Implantation
Abstract
In order to observe the morphological changes that occur in cell-cell and cell-matrix interactions among trophoblast cells and other neighbouring cells during human implantation, BeWo cells were cultured in a 3-dimensional artificial extracellular matrix (Matrigel) using a double-chamber system. These cultures were then processed for light and electron microscopical examination. Results obtained show that the morphology and behavioural pattern of BeWo cells grown on Matrigel is similar to that reported for in vitro normal human cytotrophoblast cells on extracellular matrix (ECM). These results suggest that culture of BeWo cells on extracellular matrices may be useful for the study of some of the early embryonic events leading to human implantation, especially during the period
when trophoblastic cells interact with and erode the uterine epithelium and ECM.
Keywords: BeWo cells, Trophoblast, Morphology, Matrigel, implantation
Journal of Science and Technology Vol. 28 (1) 2008 pp. 4-16
