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Published:
Jun 8, 2001Keywords:
Benzhydrylpiperazine Propanols Antispasmodic Activity Grignard's Reaction B-Piperazinyl Keynotes
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The copyright of a submitted article is only transferred to the publishers if and when the article is accepted for publication. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, mechanical, photocopying, recording or otherwise without the prior written permission of the publishers.
Main Article Content
Synthesis of some Benzhydryl Derivativies of Pipe Razinyl Propanols
Abstract
Four new derivatives ofÆ´-(4-benzhydryl-1-piperaziny)-a-phenyl propanols were prepared using Grignard’s reaction. They were isolated as solid bases and their structures, elucidated using I.R. and Hnmr spectroscopy. The compounds were screened for antispasmodic activity on guinea pig ileum, suing acetylcholine as the spasmodic agent. They all gave complete inhibition 80% maximal acetlcholine-induced contractions at microgram concentration.
