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Published:
Aug 18, 1994Keywords:
Griffonin Toxicity Erythrocyte Hemoglobin Leucopenia Haemopoiesis
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The copyright of a submitted article is only transferred to the publishers if and when the article is accepted for publication. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, mechanical, photocopying, recording or otherwise without the prior written permission of the publishers.
Main Article Content
Some Toxic-Effects of Griffonin in Mice
Abstract
Acute and subacute toxicity tests show that griffonin has slight central nervous system depressant action, resulting in reduced locomotor activity in mice. The, mice had increased urination and passed semi-solid stools, suggesting muscarinic activity. The LD50 of griffonin in mice was 4.31±0.58g/kg body weight. In the subacute toxicity tests, mice were exposed to griffonin for six weeks. Griffonin caused an initial reduction in red blood cell count which later returned to normal. Microscopic examination of sections of the lung, heart, kidney, spleen and liver showed that griffonin had no effect on the lung and spleen but had dose- and time-dependent effects on the heart, liver and kidney.
