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The copyright of a submitted article is only transferred to the publishers if and when the article is accepted for publication. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, mechanical, photocopying, recording or otherwise without the prior written permission of the publishers.
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Action on Pilocarpine on the Guinea-Pig Tracheal Chain
Abstract
The muscarinic drugs carbachol and pilocarpine were used as tone-inducing agents on the guinea-pig tracheal chain preparation in an attempt to evaluate bronchodilator activity on the tissue. Whereas carbachol produced contraction of the tissue in all the doses used, pilocarpine had an unpredictable action in that it caused contraction of some 'tissues while producing an initial relaxation of others in the dose range used. Theβ-adrenoceptor drugs isoprenaline and cimaterol were found to be more potent in-relaxing pilocarpine than carbachol-induced tone.
