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The copyright of a submitted article is only transferred to the publishers if and when the article is accepted for publication. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, mechanical, photocopying, recording or otherwise without the prior written permission of the publishers.
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Response of Falciparum Malaria in Vivo to Chloroquine in Kumasi/Ghana J.W Acheampong
Abstract
In 50 patients, who presented with malaria, the presence of Plasmodium falciparum was confirmed in thin and thick blood films. They were treated with a total dosis of 25mg/kg chloroquine base. It was noticed that in Kumasi, Ashanti Region:
- a) there is a clear evidence of decreased sensitivity of P. talciparum 10 chloroquine,
- b) chloroquine is still effective in the treatment of malaria and remains the drug of first choice unless there is history of allergy.
In 30 (60.0%) patients parasitaemia cleared within 3 days. In 18(36%) patients clearance of parasitaemia was between day 4 and day 8.
- In 2 (4%) patients there was no absolute clearance afthough there was a significant reduction of the parasitaemia (resistance of RII type).
The mean clearance time for the 48 patienals was 3.72 1.52 days.
