Article Sidebar
Published:
Jul 15, 2013DOI:
10.4314/jpb.v9i2.6Keywords:
Article Details
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
In vitro anthelmintic activity of the seed extracts of three plants of the Cucurbitaceae family on Lumbricus terrestris
Abstract
Aqueous and methanolic extracts of the seeds of Cucurbita pepo, Citrullus lanatus and Telfairia occidentalis (all of the family: Curcubitaceae) were evaluated in vitro for anthelmintic activity against Lumbricus terrestris (earthworms). Seven motile worms were released into solutions of various concentrations of extracts (2.5, 5, 10, 20, and 50mg/ml in normal saline). Albendazole (1, 2.5, 5 and 10mg/ml) and normal saline served as positive and negative controls respectively. Results were expressed in terms of time for paralysis and death of the worms. The aqueous and methanolic extracts, at all the doses tested, caused concentration-dependent paralysis and death of the worms. Cucurbita pepo was found to be most effective in killing the worms compared to C. lanatus and T. occidentalis extracts. Also, the aqueous extracts showed higher worm inhibitory and destructive activities compared to the methanol extracts. The results show that Cucurbita pepo, Citrullus lanatus and Telfairia occidentalis possess potent anthelmintic activities, thus supporting their use in traditional medicine for management of helminth infections.
Keywords: Helminth, Telfairia occidentalis, Cucurbita pepo, Citrullus lanatus, aqueous extracts
