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Published:
Jul 15, 2013DOI:
10.4314/jpb.v9i2.1Keywords:
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Main Article Content
Biochemical and histological evaluation of the effect of Sudan IV (a red dye) on renal function
Abstract
The effect of a red dye, Sudan IV on kidney function was investigated. Some biochemical parameters such as total protein, creatinine, urea, sodium, potassium, alanine aminotransferase and aspartate aminotransferase levels were determined. Histopathological analyses were also carried out. Consequently, thirty-two albino rats (Wistar strain) were divided into 4 groups of eight rats each. The groups were given 90% rat chow supplemented with 10% palm oil. Sudan IV was administered in the diet to provide levels of 0% (PO), 0.005% (PO/0.005), 0.01% (PO/0.01) and 0.015% (PO/0.015). They were given these diets for six weeks along with water ad libitum. Weekly measurements of weights were recorded. Results showed that there were no significant (P<0.05) differences in weight gain although there was slight reduction in feed intake. A significant (P<0.05) increase in the levels of total protein, creatinine, urea, aspartate aminotransferase and alanine aminotransferase levels suggest possible kidney malfunction. Histopathological analyses reveal damage to renal tissues in rats administered with the dye.
Keywords: Sudan IV; Kidney; Creatinine; Urea; Histopathological; Biochemical parameters
