Article Sidebar
Published:
Aug 28, 2012DOI:
10.4314/jpb.v8i2.10Keywords:
Article Details
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
Anticonvulsant screening and brine shrimp lethality test of some para-substituted-N-(2,6-diisopropylphenyl) benzamides
Abstract
Many antiepileptic agents are available but a search for compounds with more selectivity and lower toxicity continues to be an area of intensive investigation in drug development. Among the benzamides, N-(2,6-dimethylphenyl)-4-aminobenzamide, (Ameltolide®, LY201116) is the most potent antiepileptic agent that is yet to reach the market. In view of this, some N-(2,6-diisopropylphenyl) benzamides were synthesized and screened for anticonvulsant activity in accordance with the Antiepileptic Drug Development Program (ADD) of National Institute of Health (NIH), USA. All the four compounds screened offer partial protection against chemically induced seizure of intra peritoneal metrazol on mice but the 4-chloro compound proved to be the best among the series with a protective index of 50.21 on the brine shrimp lethality test scale.
Keywords: Anticonvulsant, Benzamide, Epilepsy and Seizures.
