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Main Article Content
Evaluation of the suspending property of grewia gum in sulphadimidine suspension
Abstract
The suspending property of grewia gum in sulphadimidine suspension was evaluated. The gum was extracted by maceration, filtration, precipitation and drying techniques. It was used at 0.3 to 1% w/v as a suspending agent for sulphadimidine. Sodiumcarboxymethylcellulose (SCMC) and tragacanth were used as basis for comparison. The suspending properties evaluated included the sedimentation rate, sedimentation volume, ease of redispersibility, apparent viscosity and degree of flocculation. Results obtained after 8 weeks of storage showed that the optimum suspending concentration for grewia gum in the drug was 1% w/v. The sedimentation rate, sedimentation volume and the viscosity of the suspension containing grewia gum were not superior to those made with SCMC. Significant (P < 0.05) difference in these properties was observed when compared with suspension containing tragacanth. The suspension containing grewia gum was moderately redispersed. The degree of flocculation decreased in the order SCMC>grewia>tragacanth. On the basis of these, grewia gum may find application as a suspending agent in sulphadimidine suspension.
