Article Sidebar
DOI:
10.4314/jpb.v7i2.11Keywords:
Article Details
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
Anti-inflammatory activity of chromatographic fractions of Stereospermum kunthianum Cham Sandrine Petit (Bignoniaceae) stem
Abstract
The study evaluates the anti-inflammatory activity of the vacuum liquid (A, B and C) and column (L, S and Y) chromatographic fractions of Stereospermum kunthianum stem bark. The fractions at the doses of 100, 200 and 400 mg/kg were evaluated using the carrageenan-induced paw oedema model in rats. The control rats received normal saline (5 ml/kg) while indomethacin (10 mg/kg) served as the reference drug. Fractions A, B and C dose-dependently and significantly (P<0.05) reduced the paw swelling (oedema) in the treated animals compared to the control animals. The maximum reduction in paw swelling was at the third hour post carrageenan injection. Indomethacin (10 mg/kg) caused a more reduction in the paw swelling compared to the fractions. Similarly, the column chromatographic fractions L, S and Y dose-dependently and significantly (P<0.05) caused a reduction in the paw swelling. The results indicate that the fractions may inhibit inflammatory responses mediated by prostaglandins and other inflammatory mediators.
Keywords: Anti-inflammatory activity, Chromatographic fractions, Stereospermum kunthianum.
