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Main Article Content
Effect of concentration on skin permeation of caffeine from gel formulations
Abstract
Various studies have considered the impact of different physico-chemical drug characteristics, skin thickness, or formulation on the absorption from the skin surface to underlying tissues or to the systemic circulation, but they rarely discuss the influence of drug concentration on the permeation flux of molecules. This research therefore aimed at studying the influence of drug concentration in a caffeine formulation. For this study, three same base gels were used at 1, 3 and 5% of caffeine to evaluate the effect of concentration on in vitro release through synthetic membrane and on ex vivo permeation of caffeine through human skin. No correlation was found between transfer through synthetic membrane and that observed through the skin. This shows that the diffusion flux of caffeine permeation does not depend on the concentration of the formulation but rather on the quantity of formulation applied. This is evidenced by the fact that the lowest lag time (Tlag) and higher absorption rates were obtained with gel at 1% of caffeine applied at 1mg/cm2.
Keywords: Absorption rate; Bioavailability; Caffeine; Diffusion flux; Lag time.
