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Keywords:
Zizyphus spina-christi Acute toxicity Aqueous extract Active principles.
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Main Article Content
Comparative acute toxicity study of the pulp, seed and stem bark (aqueous) extracts of Zizyphus spina-christi L.(Kurna)
Abstract
The toxicological potentials of the pulp, seed and stem bark (aqueous) extracts of Zizyphus spina-christi L. was investigated in rats. Acute toxicity was conducted following intraperitoneal administration of graded doses of the
plant extract. LD50 of the pulp, seed and stem bark (aqueous) extracts were 6500mg/kg, 6250mg/kg and 6000mg/kg body weight respectively. Mortality which was dose dependent occurred at high doses of 6000mg and 8000mg/kg
for the pulp, seed and stem bark extracts. Phytochemical analysis of the aqueous extracts (pulp, seed, stem bark) indicated the presence of flavonoids, alkaloids , carbohydrates, tannins and saponins. The results show that all parts of the plant can be useful for medicinal purposes.
plant extract. LD50 of the pulp, seed and stem bark (aqueous) extracts were 6500mg/kg, 6250mg/kg and 6000mg/kg body weight respectively. Mortality which was dose dependent occurred at high doses of 6000mg and 8000mg/kg
for the pulp, seed and stem bark extracts. Phytochemical analysis of the aqueous extracts (pulp, seed, stem bark) indicated the presence of flavonoids, alkaloids , carbohydrates, tannins and saponins. The results show that all parts of the plant can be useful for medicinal purposes.
