Article Sidebar
Keywords:
Article Details
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
Total lipid profile with aqueous fruit extract of Solanum macrocarpum Linn. in hypercholesterolaemic albino rats
Abstract
Studies were undertaken to investigate the effects of the aqueous fruit extract of Solanum macrocarpum Linn. on the total lipid profile: total cholesterol, triglycerides, high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) on hypercholesterolaemic rats. Total serum cholesterol, triglycerides and LDL-C were lowered in the hypercholesterolaemic rats with increasing dose of the extract whilst serum HDL-C increased. These changes however were not significant (p > 0.05) when compared to the control. The results show that the aqueous fruit extract of the plant may be capable of reducing circulating lipids in high cholesterol-diet fed rats. However, more work still needs to be done on this as the changes in the serum lipid profile were not significant so as to determine whether the plant either inhibits lipid biosynthesis or stimulates lipid catabolism.
Keywords: Solanum macrocarpum; Triglycerides; Cholesterol; LDL-cholesterol; HDL-cholesterol; Aqueous extract
