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Main Article Content
Effect of some surfactants on the release of metronidazole from suppositories formulated with goat fat and palm kernel oil admixtures
Abstract
Metronidazole (MDZ) suppositories were formulated by pour moulding using goat fat (GF)–palm kernel oil (PKO) admixture (3:1) as the base. The effect of three surfactants – cationic (cetrimide), anionic (sodium laurylsulphate) and non-ionic (Tween 65) was evaluated. The mechanism of release of the active ingredient from the suppositories was equally investigated. It was found that Tween 65 (T-65) and sodium laurylsulphate (SLS) improved the release of MDZ significantly (p>0.05) at all the concentrations used. Cetrimide (CTM) did not improve the release of MDZ at all the concentrations used. It was also found that release of MDZ from the suppositories was largely governed by diffusion. Statistical analysis (p>0.05) of the results showed T-65 performed better than SLS in enhancing the release of MDZ from the suppositories, and could be used to enhance the release of MDZ from suppositories formulated with this novel suppository base.
Keywords: Surfactants; Goat fat; Palm kernel oil; Metronidazole; Suppositories; Drug release
