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Main Article Content
Anti-inflammatory and antibacterial activity of E-3- arylidene flavanones synthesized by one-pot method
Abstract
The objective of the present study was to synthesize E-3-arylidene flavanones by one-pot method and screen them for anti-inflammatory and antibacterial activity. A set of four E-3-arylidene flavanones were synthesized by simple base-catalyzed condensation of appropriate aryl aldehydes and 2'-hydroxy acetophenone. Screening for the antiinflammatory activity was done by carrageenan-induced paw edema method. Test for antibacterial activity was carried out by cup-plate method. Due to structural similarity with natural flavanones, all the synthesized compounds were expected to exhibit some activity, however only three of the compounds exhibited anti-inflammatory and antibacterial action.
Keywords: E-3-Arylidene flavanone; One-pot method; Anti-inflammatory activity; Antibacterial activity
