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Main Article Content
Pharmacokinetics of chloroquine in diabetic rabbits
Abstract
The pharmacokinetic parameters derived from diabetic rabbits have been compared to those of normal rabbits. Two sets of rabbits were used, normal rabbits and diabetic rabbits. The diabetic rabbits were obtained by inducing diabetes in rabbits using streptozotocin. Chloroquine at a dose of 10 mg/kg was administered to this set of rabbits by oral administration. Blood samples were obtained from the rabbits at suitable time intervals and they were analyzed for chloroquine concentrations. From the plasma-concentration profile, the pharmacokinetic parameters such as the half-life of absorption, the absorption rate constant (ka), the half-life of elimination (t½el) and elimination rate constant (kel), the time lag, (Tlag) area under the curve AUC, the volume of distribution (Vd), and the plasma clearance (Pcl) were determined and compared. It was found that some of the pharmacokinetic parameters such as volume of distribution (Vd), plasma clearance (Pcl) and area under the curve AUC differ significantly (p > 0.05) in the diabetic rabbits compared to normal rabbits. This is an indication that chloroquine is less metabolized in the diabetic rabbits than in the normal rabbits, therefore indicating impairment of metabolism in the diabetic rabbits.
Keywords: Pharmacokinetics, Chloroquine, Rabbits, Diabetes
