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Published:
Aug 6, 2007Keywords:
<i>Enantia chlorantha Nauclea latifolia</i> Analgesic activity Anti-inflammatory activity Phytoconstituents
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Main Article Content
Acute toxicity studies, anti-inflammatory and analgesic activities of the methanolic extract of the stem bark of Enantia chlorantha and Nauclea latifolia
Abstract
Methanolic extracts of the stem bark of Enantia chlorantha and Nauclea latifolia were investigated in rats and mice for anti-inflammatory and analgesic activities. The activities of the extracts were tested on egg white-induced oedema, acetic acid-induced writhing and hot plate models. Methanolic extract of Nauclea latifolia was found to be very toxic with an LD50 of 0.852 g/kg. The LD50Enantia chlorantha was 2.588 g/kg. At low concentrations,Nauclea latifolia (150 mg and 500 mg) extract was found to have weak analgesic and anti-inflammatory effects. Enantia chlorantha extract was found to possess anti-inflammatory and analgesic activities, at higher doses (400 mg and 1100 mg/Kg). Higher dose was not used for Nauclea latifolia because of its toxicity in experimental animals. Phytochemical tests revealed that both extracts contain mainly flavonoids, tannins and low concentration of glycosides. The results from this study support the claims by traditional healers that these plants have analgesic and anti-inflammatory properties.
Keywords: Enantia chlorantha; Nauclea latifolia; Analgesic activity, Anti-inflammatory activity; Phytoconstituents
Journal of Pharmacy and Bioresources Vol. 3 (2) 2006: pp. 111-115
