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Published:
Aug 6, 2007Keywords:
Indomethacin Pig gastric mucus Grewia gum Bioadhesive performance
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Main Article Content
Evaluation of the bioadhesive property of Grewia gum in indomethacin tablet formulation in pig gastric mucus
Abstract
The bioadhesive property of grewia gum for sustained release of Indomethacin from tablets was evaluated using pig gastric mucus as substrate. The tablets formulated by wet granulation contained 75 mg of the drug and 15 or 20 %w/w of the gum. Similar tablets made differently with carbopol 934, tragacanth and sodium carboxymethylcellulose (SCMC) were used as basis for comparison. Hydration of tablets and substrate surfaces was done using 0.1N hydrochloric acid and phosphate buffer providing pH values of 1.2 and 7.4 respectively. The force required to detach the tablets from substrate surface was determined in a testometric material testing machine. Drug release from polymer matrix tablets was fastest for tragacanth and slowest for carbopol 934. The detachment force of tablets from substrate was found to increase in the order: carbopol 934 > SCMC > grewia gum > tragacanth. The detachment force was affected by the pH of the hydration medium. On the basis of these grewia gum may find application as bioadhesive polymer for sustained release tablet formulation.
Keywords: Indomethacin; Pig gastric mucus, Grewia gum, Bioadhesive performance
Journal of Pharmacy and Bioresources Vol. 3 (2) 2006: pp. 62-69
