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Published:
Sep 16, 2008Keywords:
Hypermotility Noradrenergic pathway Diazepam GABA Receptors
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Main Article Content
Non-invasive and non-chemical method of stimulating the brain and inducing hypermotility in normal Wistar rats
Abstract
The effect of diffuse transcranial electrical stimulation (DTES) on motility was investigated in healthy male and female Wistar rats. Diffuse transcranial electrical stimulation (5V, frequency 100Hz, pulse width 1ms), was delivered with the aid of ear clip electrodes, while locomotor activity was measured with the aid of motility counter for 10 seconds before, during and after stimulation. Diffuse transcranial electrical stimulation was found to induce reproducible hypermotility in the rats. Locomotor activity in normal rats, measured for 10 seconds, averaged 10.1±4.1 before stimulation. The activity significantly (p<0.001) increased to 81.8±13.5 during first stimulation and significantly (p<0.05) dropped after stimulation. When stimulation was repeated 30 minutes later, motility count was insignificantly (P>0.05) lower than the former, but followed the same course as the later. Locomotor activity after DTES did not significantly (p>0.05) vary from the values obtained before and after electrical stimulation. These results suggest that diffuse transcranial electrical stimulation produces reproducible hyper-motility which is inhibited by diazepam in normal conscious rats. DTES may serve as a simple method of stimulating the CNS and increasing its levels of catecholamines. The inhibition by diazepam further shows that brain catecholamines are raised during stimulation.
Keywords: Hypermotility, Noradrenergic pathway, Diazepam, GABA Receptors
Journal of Pharmacy and Bioresources Vol. 4 (1) 2007: pp. 14-19
