Article Sidebar
Published:
Oct 5, 2006Keywords:
hypotensive effect <i> Baissea axillaris</i> normotensive rabbits
Article Details
Issue
Section
Articles
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
Hypotensive effect of Baissea axillaris (Apocynaceae) leaves in normotensive rabbits
Abstract
Baissea axillaris leaves are used in ethnomedicine to reduce elevated blood pressure. The effect of the aqueous extract of the leaves (obtained by decoction method) on blood pressure was tested on normotensive rabbits intravenously (i.v.) at doses of 2.5, 5, 10, and 20 mg/kg. The probable mechanism of action of the extract was examined by prior administration of atropine (0.5mg/kg i.v.) or promethazine (0.25mg/kg i.v.) followed by administration of the water extract . The effects of chloroform fraction was tested at tested at 0.625,1.25, 2.5mg/kg while the n-butanol fraction was tested at 2.5,5,10, 25, 50,and 100mg/kg dose points. The aqueous extract showed a dose-dependent reduction in blood pressure which was found to be significantly blocked by prior administration of atropine or promethazine. The chloroform fraction of the extract showed higher significant blood pressure lowering (hypotensive) activity than both the extract and n-butanol fraction. The leaves of B. axillaris have hypotensive action on blood pressure as claimed by ethnomedical practitioners.
Journal of Pharmacy & Bioresources Vol. 2(2) 2005: 84-88
Journal of Pharmacy & Bioresources Vol. 2(2) 2005: 84-88
